The film tells the story of Peter, who is forced to voluntarily erase himself from the memories of his loved ones and must now struggle with the physical changes he is undergoing as he fights crime alone on the streets of New York, where no one knows his true identity.

Peter, who has voluntarily erased himself from the memories of his loved ones, now lives as a completely solitary adult, fighting crime on the streets of New York—a city where no one even knows his name. Peter, a “full-time” Spider-Man who has dedicated himself entirely to protecting his city, is grappling with a surprising physical evolution triggered by the pressure he faces, while a mysterious wave of crime pits him against one of the most powerful threats he has ever faced.